Quantum dots are nanoscale crystals often known as man-made molecules. They have excellent photo-optic properties, and in conjunction with their size, they can be fitted and suited for direct delivery systems of specifically chemotherapeutic drugs. For ApolloQD, these properties will be utilized to construct a quantum dot bioconjugate (QDBC) for direct delivery of chemo drugs cyclophosphamide and fludarabine to treat CLL (chronic lymphocytic leukemia).
In order for quantum dots to even stand a chance in the space of direct delivery, they must be biologically conjugated, which means being built upon and somewhat "fused" with organic materials. These organic materials include ligands, liposomes, antibodies, and nuclear localization sequences (NLS)...
By utilizing these quantum dots in treating leukemia, we must first understand the process by which this would occur with our bioconjugate system. There are 5 main steps...
Overall, the QDBC encapsulates compound chemotherapy, and by using targetting ligands, the system enters a leukemic cell and destroys the cancerous cell. This overall improves accuracy of chemotherapy treatment, in addition to making it much less harmful than conventional chemo.
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